USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P30101 USC-OGP 2-DE database:  P30101 P30101 General information about the entry View entry in simple text format Entry name PDIA3_HUMAN Primary accession number P30101 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Protein disulfide-isomerase A3; EC=5.3.4.1; AltName: Full=58 kDa glucose-regulated protein; AltName: Full=58 kDa microsomal protein; Short=p58; AltName: Full=Disulfide isomerase ER-60; AltName: Full=Endoplasmic reticulum resident protein 57; Short=ER protein 57; Short=ERp57; AltName: Full=Endoplasmic reticulum resident protein 60; Short=ER protein 60; Short=ERp60; Flags: Precursor;. Gene name Name=PDIA3 Synonyms=ERP57, ERP60, GRP58 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0343: pI=5.34; Mw=54833 SPOT OGP-0346: pI=5.40; Mw=54664 SPOT OGP-0347: pI=5.46; Mw=54664 SPOT OGP-0350: pI=5.55; Mw=54328 SPOT OGP-0424: pI=5.48; Mw=40808 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0652: pI=5.41; Mw=55942 SPOT OGP-0653: pI=5.48; Mw=55779 SPOT OGP-0655: pI=5.57; Mw=55616 SPOT OGP-0715: pI=5.49; Mw=41434 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1151: pI=5.63; Mw=55013 SPOT OGP-1153: pI=5.74; Mw=54155 SPOT OGP-1154: pI=6.30; Mw=54155 SPOT OGP-1247: pI=5.77; Mw=31502 Cross-references UniProtKB/Swiss-Prot P30101; PDIA3_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PDIA3_HUMAN Primary accession number P30101 Secondary accession number(s) Q13453 Q14255 Q8IYF8 Q9UMU7 Sequence was last modified on  November 1, 1997 (version 4) Annotations were last modified on  March 15, 2017 (version 203) Name and origin of the protein Description RecName: Full=Protein disulfide-isomerase A3; EC=5.3.4.1; AltName: Full=58 kDa glucose-regulated protein; AltName: Full=58 kDa microsomal protein; Short=p58; AltName: Full=Disulfide isomerase ER-60; AltName: Full=Endoplasmic reticulum resident protein 57; Short=ER protein 57; Short=ERp57; AltName: Full=Endoplasmic reticulum resident protein 60; Short=ER protein 60; Short=ERp60; Flags: Precursor; Gene name Name=PDIA3 Synonyms=ERP57, ERP60, GRP58 Encoded on Name=PDIA3; Synonyms=ERP57, ERP60, GRP58 Keywords 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Isomerase; Methylation; Phosphoprotein; Polymorphism; Redox-active center; Reference proteome; Repeat; Signal. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D16234; BAA03759.1; -; mRNA EMBL U42068; AAC50331.1; -; mRNA EMBL Z49835; CAA89996.1; -; mRNA EMBL U75885; AAC51518.1; -; Genomic_DNA EMBL U75875; AAC51518.1; JOINED; Genomic_DNA EMBL U75876; AAC51518.1; JOINED; Genomic_DNA EMBL U75877; AAC51518.1; JOINED; Genomic_DNA EMBL U75878; AAC51518.1; JOINED; Genomic_DNA EMBL U75879; AAC51518.1; JOINED; Genomic_DNA EMBL U75880; AAC51518.1; JOINED; Genomic_DNA EMBL U75881; AAC51518.1; JOINED; Genomic_DNA EMBL U75882; AAC51518.1; JOINED; Genomic_DNA EMBL U75883; AAC51518.1; JOINED; Genomic_DNA EMBL U75884; AAC51518.1; JOINED; Genomic_DNA EMBL D83485; BAA11928.1; -; mRNA EMBL BC014433; AAH14433.1; -; mRNA EMBL BC036000; AAH36000.4; -; mRNA EMBL BC071878; AAH71878.1; -; mRNA CCDS CCDS10101.1; -; . PIR JC5704; JC5704; . PIR S55507; S55507; . PIR S63994; S63994; . PIR S68363; S68363; . RefSeq NP_005304.3; NM_005313.4; . UniGene Hs.591095; -; . PDB 2ALB; NMR; -; A=25-137 PDB 2DMM; NMR; -; A=357-485 PDB 2H8L; X-ray; 2.00 A; A/B/C=134-376 PDB 3F8U; X-ray; 2.60 A; A/C=25-505 PDBsum 2ALB; -; . PDBsum 2DMM; -; . PDBsum 2H8L; -; . PDBsum 3F8U; -; . ProteinModelPortal P30101; -; . SMR P30101; -; . BioGrid 109180; 125; . DIP DIP-29132N; -; . IntAct P30101; 76; . MINT MINT-5000005; -; . STRING 9606.ENSP00000300289; -; . iPTMnet P30101; -; . PhosphoSitePlus P30101; -; . SwissPalm P30101; -; . BioMuta PDIA3; -; . DMDM 2507461; -; . DOSAC-COBS-2DPAGE P30101; -; . REPRODUCTION-2DPAGE P30101; -; . SWISS-2DPAGE P30101; -; . UCD-2DPAGE P30101; -; . EPD P30101; -; . PaxDb P30101; -; . PeptideAtlas P30101; -; . PRIDE P30101; -; . TopDownProteomics P30101; -; . DNASU 2923; -; . Ensembl ENST00000300289; ENSP00000300289; ENSG00000167004; . GeneID 2923; -; . KEGG hsa:2923; -; . CTD 2923; -; . DisGeNET 2923; -; . GeneCards PDIA3; -; . HGNC HGNC:4606; PDIA3; . HPA CAB011199; -; . HPA CAB015181; -; . HPA HPA002645; -; . HPA HPA003230; -; . MIM 602046; gene; . neXtProt NX_P30101; -; . OpenTargets ENSG00000167004; -; . PharmGKB PA29000; -; . eggNOG KOG0190; Eukaryota; . eggNOG COG0526; LUCA; . GeneTree ENSGT00860000133691; -; . HOGENOM HOG000162459; -; . HOVERGEN HBG005920; -; . InParanoid P30101; -; . KO K08056; -; . OMA QINFAIA; -; . OrthoDB EOG091G05J9; -; . PhylomeDB P30101; -; . TreeFam TF106382; -; . BRENDA 5.3.4.1; 2681; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-901042; Calnexin/calreticulin cycle; . Reactome R-HSA-983170; Antigen Presentation: Folding; assembly and peptide loading of class I MHC; . ChiTaRS PDIA3; human; . EvolutionaryTrace P30101; -; . GenomeRNAi 2923; -; . PRO PR:P30101; -; . Proteomes UP000005640; Chromosome 15; . Bgee ENSG00000167004; -; . CleanEx HS_PDIA3; -; . ExpressionAtlas P30101; baseline and differential; . Genevisible P30101; HS; . GO GO:0009986; C:cell surface; IDA:MGI; . GO GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB; . GO GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0045335; C:phagocytic vesicle; TAS:Reactome; . GO GO:0055038; C:recycling endosome membrane; TAS:Reactome; . GO GO:0004197; F:cysteine-type endopeptidase activity; TAS:ProtInc; . GO GO:0015036; F:disulfide oxidoreductase activity; TAS:ParkinsonsUK-UCL; . GO GO:0004629; F:phospholipase C activity; TAS:ProtInc; . GO GO:0003756; F:protein disulfide isomerase activity; IBA:GO_Central; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome; . GO GO:0045454; P:cell redox homeostasis; IEA:InterPro; . GO GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl; . GO GO:0006457; P:protein folding; TAS:Reactome; . GO GO:0034975; P:protein folding in endoplasmic reticulum; TAS:ParkinsonsUK-UCL; . GO GO:0006606; P:protein import into nucleus; TAS:ProtInc; . GO GO:0006621; P:protein retention in ER lumen; TAS:ProtInc; . GO GO:0034976; P:response to endoplasmic reticulum stress; IBA:GO_Central; . GO GO:0007165; P:signal transduction; TAS:ProtInc; . Gene3D 3.40.30.10; -; 3; . InterPro IPR005788; Disulphide_isomerase; . InterPro IPR005792; Prot_disulphide_isomerase; . InterPro IPR012336; Thioredoxin-like_fold; . InterPro IPR017937; Thioredoxin_CS; . InterPro IPR013766; Thioredoxin_domain; . Pfam PF00085; Thioredoxin; 2; . SUPFAM SSF52833; SSF52833; 4; . TIGRFAMs TIGR01130; ER_PDI_fam; 1; . TIGRFAMs TIGR01126; pdi_dom; 2; . PROSITE PS00194; THIOREDOXIN_1; 2; . PROSITE PS51352; THIOREDOXIN_2; 2; .

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